Opioid Use Disorder Statistics in South Carolina

Comprehensive Opioid Use Disorder statistics for South Carolina, including prevalence, demographics, treatment access, and outcomes data.

3 min read
8.6%[1]
Decrease in Opioid-Related Deaths in South Carolina (2022-2023)

South Carolina saw a significant reduction in opioid-involved overdose fatalities, with 1,704 deaths in 2023 compared to 1,864 in 2022.

2022-2023

Key Takeaways

  • South Carolina experienced its first decline in overall drug overdose deaths since 2014, with a 6.1% decrease in 2023.2,157 deaths[2]
  • The number of Medicaid beneficiaries with Opioid Use Disorder surged by 20.2% in one year, indicating a growing need for care among low-income populations.18,181 people[3]
  • Significant racial disparities persist in treatment access; Black Medicaid patients have markedly lower odds of initiating medications for OUD compared to their White counterparts.AOR of 0.29[4]
  • A critical treatment gap exists following overdose events, with only 7.6% of Medicaid enrollees starting OUD medication within 30 days of an opioid-related ER visit.7.6%[1]
  • Fentanyl remains the primary driver of fatal overdoses in the state, accounting for 1,550 deaths in 2023 despite a slight decrease from the previous year.1,550 deaths[2]
  • Rural areas in South Carolina are disproportionately affected by the opioid crisis, facing significant barriers including fewer treatment facilities and lower provider density.[2]

The Opioid Crisis in South Carolina: An Overview

The opioid crisis in South Carolina presents a complex picture of both progress and persistent challenges. In 2023, the state saw a promising 6.1% decrease in total drug overdose deaths, marking the first annual decline since 2014[2]. However, the crisis continues to exact a heavy toll, with potent synthetic opioids like fentanyl remaining a primary cause of fatalities[5]. Understanding the data behind prevalence, treatment access, and outcomes is crucial for shaping effective public health strategies across the state.

Prevalence of Opioid Use Disorder and Mental Health Conditions

The impact of substance use extends far beyond overdose statistics, affecting hundreds of thousands of South Carolinians. An estimated 3.1% of adults in the state have an Opioid Use Disorder[6]. This often co-occurs with other mental health challenges, as 22.5% of adults reported any mental illness in the past year, and 5.2% experienced a serious mental illness[6]. These interconnected issues highlight the need for integrated care that addresses both substance use and mental health concurrently.

3.1%[6]
Adults with Opioid Use Disorder

Estimated 12-month prevalence among adults in South Carolina.

2023
22.5%[6]
Adults with Any Mental Illness

Percentage of adults aged 18+ reporting any mental illness in the past year.

2023
18,181[2]
Medicaid Beneficiaries with OUD

This represents a 20.2% increase from 2022, highlighting the crisis's impact on low-income groups.

2023
13.3%[7]
Opioid Use Among Incarcerated Individuals

Prevalence rate found during routine screening in SC correctional facilities, up slightly from 2022.

2023

Disparities in Treatment and Access to Care

Access to effective treatment is not uniform across South Carolina. Significant disparities exist, particularly for racial minorities and residents of rural areas. Research shows that Black Medicaid enrollees are far less likely to begin evidence-based treatment compared to White enrollees, pointing to systemic barriers within the healthcare system[4]. Factors such as healthcare mistrust, financial constraints, and stigma contribute to these gaps, especially for Black men in rural communities[8].

Likelihood of Initiating OUD Medication (MOUD) for Medicaid Patients
Baseline
White Patients
71% Lower Odds
Black Patients
Adjusted odds ratio of 0.29 for Black patients
This stark disparity indicates that Black Medicaid patients face significant systemic barriers to accessing proven, life-saving treatment for Opioid Use Disorder compared to their White counterparts.

Systemic Barriers to Treatment

Beyond demographic disparities, structural issues limit treatment access statewide. A significant treatment gap exists nationally, with estimates suggesting up to 85% of people with substance use disorders do not receive care[1]. In South Carolina, this is exacerbated by a shortage of providers, as nearly two-thirds of counties are designated as Health Professional Shortage Areas for mental health[9]. These shortages, combined with stigma and logistical challenges like transportation, create formidable barriers, particularly in rural regions[10].

7.6%[4]
MOUD Initiation After an ER Visit

Of SC Medicaid patients with an opioid-related ER visit, only 7.6% started medication within 30 days.

2021
65%[9]
Counties Designated as Mental Health HPSAs

Nearly two-thirds of SC counties are considered Health Professional Shortage Areas for mental health care.

5,506[11]
Patients in Public OUD Treatment

Number of individuals treated for OUD at public facilities in 2023, a 1.0% decrease from 2022.

2023
120 per 100k[9]
Mental Health Providers

South Carolina has approximately 120 mental health providers per 100,000 people.

Opioid Prescriptions Dispensed (per 1,000 residents)
649
2022
627
2023
3.5% Decrease
Statewide efforts to promote responsible prescribing practices are showing results, with a continued reduction in the number of opioid prescriptions.
Naloxone Administrations by EMS
14,105
2022
11,151
2023
20.9% Decrease
The significant drop in naloxone administrations by first responders may correlate with the overall decline in overdose incidents.

Frequently Asked Questions

Sources & References

All statistics and claims on this page are supported by peer-reviewed research and official government data sources.

1South Carolina Opioid Data - Just Plain Killers. Justplainkillers. Published 2022. Accessed January 2026. https://justplainkillers.com/data/
2Opioid Epidemic | South Carolina Department of Public Health. Dph. Published 2023. Accessed January 2026. https://dph.sc.gov/diseases-conditions/substance-use-prevention-resources/opioid-epidemic
3Trends in Access to Medications for Opioid Use Disorder. JAMA Network. Accessed January 2026. https://jamanetwork.com/journals/jama-health-forum/fullarticle/2831936
4Initiation and retention of opioid use disorder treatment medication .... ScienceDirect. Published 2021. Accessed January 2026. https://www.sciencedirect.com/science/article/pii/S2949875925002474
5[PDF] 2020-SC-County-Level-Profiles-on-Substance-Use-Related .... Daodas. Published 2018. Accessed January 2026. https://www.daodas.sc.gov/wp-content/uploads/2021/02/2020-SC-County-Level-Profiles-on-Substance-Use-Related-Indicators.pdf
62023 Uniform Reporting System (URS) Table For South Carolina. Substance Abuse and Mental Health Services Administration. Published 2023. Accessed January 2026. https://www.samhsa.gov/data/report/2023-uniform-reporting-system-urs-table-south-carolina
7Treatment for Opioid Use Disorder: Population Estimates - CDC. Centers for Disease Control and Prevention. Published 2022. Accessed January 2026. https://www.cdc.gov/mmwr/volumes/73/wr/mm7325a1.htm
8Exploring Socio-Ecological and Structural Factors Among Black Men .... PubMed Central. PMC12301612. Accessed January 2026. https://pmc.ncbi.nlm.nih.gov/articles/PMC12301612/
9[PDF] South Carolina 2024 Uniform Reporting System Mental Health Data .... Substance Abuse and Mental Health Services Administration. Accessed January 2026. https://www.samhsa.gov/data/sites/default/files/reports/rpt56421/South%20Carolina.pdf
10Barriers to opioid use disorder treatment in rural US. ScienceDirect. Accessed January 2026. https://www.sciencedirect.com/science/article/abs/pii/S0277953624001047
11[PDF] Results from the 2023 National Survey on Drug Use and Health. Substance Abuse and Mental Health Services Administration. Published 2023. Accessed January 2026. https://www.samhsa.gov/data/sites/default/files/reports/rpt47095/National%20Report/National%20Report/2023-nsduh-annual-national.pdf
12Some states, plans limit access to opioid use disorder treatment .... Sc. Published 2024. Accessed January 2026. https://sc.edu/study/colleges_schools/public_health/about/news/2024/buprenorphine_prior_authorization_hspm_andrews.php
13[PDF] Drug Overdose Deaths - South Carolina Department of Public Health. Dph. Published 2023. Accessed January 2026. https://dph.sc.gov/sites/scdph/files/2025-03/Drug-Overdose-Report-2023.pdf
14[PDF] Access to Medications for Opioid Use Disorder in Medicaid - MACPAC. Macpac. Published 2025. Accessed January 2026. https://www.macpac.gov/wp-content/uploads/2025/06/MACPAC_June-2025-Chapter-3.pdf