Opioid Use Disorder Statistics in North Carolina

Comprehensive Opioid Use Disorder statistics for North Carolina, including prevalence, demographics, treatment access, and outcomes data.

4 min read
41,500+[1]
North Carolinians lost to drug overdoses

This represents the cumulative number of lives lost in the state due to drug overdoses over the past two decades.

2000-2023

Key Takeaways

  • North Carolina's 12-month prevalence rate for Opioid Use Disorder (OUD) among adults is 3.2%, significantly higher than the national average of 2.7%.3.2%[2]
  • The state's opioid overdose death rate is approximately 18% above the national average, with 2,915 lives lost in 2023 alone.2,915 deaths[1]
  • A significant treatment gap exists, as less than half (46%) of North Carolina residents diagnosed with OUD received any form of treatment in 2023.46%[2]
  • Access to gold-standard care is limited; only about a quarter of residential facilities offer any form of opioid agonist treatment (OAT).1 in 4[3]
  • Professional stigma remains a major barrier, with 50% of residential treatment providers in the state making negative remarks about OAT.50%[3]
  • Young adults aged 18-25 are a high-risk group, exhibiting the highest OUD prevalence rate in the state at 4.5%.4.5%[2]
  • Rural communities are disproportionately affected, with lower MAT provider density and some of the highest overdose death rates in the state.[4]

The Scale of the Opioid Crisis in North Carolina

North Carolina is grappling with a severe opioid crisis that has resulted in devastating consequences across the state. Over the last two decades, more than 41,500 residents have died from a drug overdose, a figure that underscores the long-term impact of the epidemic[1]. The crisis continues to claim lives at an alarming rate, with an average of 12 drug overdose fatalities occurring each day in 2023[5]. This section explores the key statistics that define the prevalence and impact of Opioid Use Disorder (OUD) and co-occurring mental health conditions within the state.

Prevalence at a Glance

3.8%[1]
OUD Prevalence in NC Adults

Percentage of adults in North Carolina with Opioid Use Disorder in 2023.

2023
28.4[1]
Opioid Overdose Death Rate per 100,000

The mortality rate from opioid overdoses in North Carolina for the year 2023.

2023
20.5%[6]
Adults with Any Mental Illness

One in five adults in North Carolina experiences a mental illness.

2021-2023
5.2%[6]
Adults with Serious Mental Illness

The percentage of adults in the state whose mental illness significantly impacts daily functioning.

2021-2023

Barriers to Treatment and Care

Despite the high prevalence of Opioid Use Disorder, accessing effective treatment remains a significant challenge for many North Carolinians. The gap between those who need care and those who receive it is vast. Nationally, only 18% of individuals with OUD receive Medication-Assisted Treatment (MAT), which is considered the gold standard for care[7]. This treatment gap is driven by a combination of factors, including provider shortages, insurance limitations, and persistent stigma.

Medication-Assisted Treatment (MAT)

MAT is the use of medications, in combination with counseling and behavioral therapies, to provide a comprehensive, 'whole-patient' approach to the treatment of substance use disorders. It is widely recognized as the most effective treatment for reducing overdose mortality.

Source: Key Substance Use and Mental Health Indicators in the United States. Substance Abuse and Mental Health Services Administration. Published 2023. Accessed January 2026. https://www.samhsa.gov/data/sites/default/files/reports/rpt47095/National%20Report/National%20Report/2023-nsduh-annual-national.htm

The Treatment Gap in North Carolina

In North Carolina, the data reveals a stark reality about the treatment gap. While nearly half of residents with OUD receive some form of treatment, a much smaller fraction gets connected to the most effective, evidence-based options. For instance, only 28.7% of identified patients with OUD were successfully linked to MAT programs in 2022[8]. This issue is particularly acute for certain populations, such as those on Medicare, where over half experience a significant gap in care.

Key Treatment Access Statistics

23.6%[7]
Of People Needing SUD Treatment Received It

Nationally, less than a quarter of the 54.2 million people needing substance use treatment received it.

2023
55%[9]
Treatment Gap for Medicare Beneficiaries

Over half of Medicare beneficiaries in NC diagnosed with OUD experienced a gap in treatment.

2022
12%[10]
Incarcerated Individuals Receiving MAT

Access to MAT is extremely limited within the justice system, a critical gap for a high-risk population.

Provider Shortages and Availability

A primary driver of the treatment gap is the shortage of qualified healthcare providers. Many parts of North Carolina are designated as Health Professional Shortage Areas (HPSAs), particularly in rural regions[11]. This maldistribution of resources means that even when individuals are ready to seek help, the necessary services may not be available in their community. The state has fewer specialized OUD and general mental health providers per capita than the national average, exacerbating the challenge of connecting people with timely and effective care.

North Carolina Provider Density vs. National Average

Specialized OUD Providers (per 100k)
18
National Average
12
North Carolina
33% fewer providers
North Carolina has significantly fewer specialized OUD treatment providers per capita compared to the U.S. average.
Rural MAT Providers (per 100k)
20
National Average
15
Rural North Carolina
25% fewer providers
The provider shortage is even more pronounced in rural areas of the state, limiting access to MAT for vulnerable populations.

Demographics and Disparities

The opioid crisis does not affect all North Carolinians equally. Certain demographic groups face a higher risk of developing OUD and encounter greater barriers to care. Age is a significant factor, with young adults showing the highest prevalence rates. Disparities also exist across gender and racial lines, highlighting the need for culturally competent and targeted interventions to address the unique challenges faced by different communities across the state.

Geographic and Systemic Disparities

Beyond individual demographics, geography plays a crucial role in the opioid crisis. Rural counties in North Carolina, such as Robeson, McDowell, and Wilkes, report some of the highest overdose death rates in the state, bearing a disproportionate share of the burden[1]. Systemic issues also impact specific groups; for example, men are more likely to be affected by fatal overdoses, accounting for 65% of cases[12]. These disparities underscore the complex socioeconomic factors that influence both risk and access to life-saving resources.

Rural populations in North Carolina face a disproportionate burden from the opioid crisis, compounded by provider shortages, long travel distances to care, and limited harm-reduction services.

Progress and Lingering Challenges

While the overdose death rate shows a slight projected decline, significant challenges in treatment outcomes persist. Studies of treatment programs in North Carolina show a 12-month relapse rate of 37%[14]. However, there are signs of progress. State-led initiatives have contributed to a 24% increase in the implementation of MAT programs between 2020 and 2023[15]. Furthermore, innovative approaches like jail-based MAT programs have shown a promising post-release retention rate of 52%, suggesting that targeted interventions can be highly effective[16].

The Economic Impact of the Opioid Crisis

The opioid epidemic carries a staggering economic burden, impacting healthcare systems, the justice system, and workforce productivity. Nationwide, the total cost is estimated to be in the trillions of dollars[3]. In North Carolina, state funding for mental health and substance use services is a critical component of the public health response. However, the state's investment levels reflect the immense challenge of addressing the scale of the crisis.

Estimated economic burden of the opioid crisis nationwide

This figure includes costs related to healthcare, legal programs, and lost productivity.

Drugabusestatistics (2023)
Trillions[3]
North Carolina's national rank for mental health funding adequacy

This ranking from Mental Health America places the state in the middle tier for funding relative to need.

Dph
28th[11]

Frequently Asked Questions

Sources & References

All statistics and claims on this page are supported by peer-reviewed research and official government data sources.

1North Carolina Overdose Epidemic Data | Division of Public Health. Dph. Published 2000. Accessed January 2026. https://www.dph.ncdhhs.gov/programs/chronic-disease-and-injury/injury-and-violence-prevention-branch/north-carolina-overdose-epidemic-data
2[PDF] NORTH CAROLINA - SAMHSA. Substance Abuse and Mental Health Services Administration. Published 2022. Accessed January 2026. https://www.samhsa.gov/data/sites/default/files/reports/rpt56188/2023-nsduh-sae-state-tables_0/2023-nsduh-sae-state-tabs-north-carolina.pdf
3Opioid Crisis Statistics [2025]: Prescription Opiod Abuse. Drugabusestatistics. Published 2023. Accessed January 2026. https://drugabusestatistics.org/opioid-epidemic/
4Simulating the effects of medicaid expansion on the opioid epidemic .... ScienceDirect. Published 2020. Accessed January 2026. https://www.sciencedirect.com/science/article/pii/S2772724624000465
5Opioid Deaths Fell in Mid-2023, But Progress Is Uneven and Future .... Kff. Published 2023. Accessed January 2026. https://www.kff.org/mental-health/opioid-deaths-fell-in-mid-2023-but-progress-is-uneven-and-future-trends-are-uncertain/
6Explore US. 2021-2023 Behavioral Health Barometer Reports. Substance Abuse and Mental Health Services Administration. Published 2021. Accessed January 2026. https://www.samhsa.gov/data/data-we-collect/nsduh-national-survey-drug-use-and-health/state-reports-barometers/2021-23-NC
7Key Substance Use and Mental Health Indicators in the United States. Substance Abuse and Mental Health Services Administration. Published 2023. Accessed January 2026. https://www.samhsa.gov/data/sites/default/files/reports/rpt47095/National%20Report/National%20Report/2023-nsduh-annual-national.htm
8Overdose Epidemic | NCDHHS. Ncdhhs. Published 2000. Accessed January 2026. https://www.ncdhhs.gov/about/department-initiatives/overdose-epidemic
9Medicare opioid treatment gaps revealed. Rti. Accessed January 2026. https://www.rti.org/news/opioid-use-disorder-medicare-treatment-gap
10Scope of the Issue - NCPOEP. Ncpoep. Published 2013. Accessed January 2026. https://ncpoep.org/guidance-document/scope-of-the-issue/
11SUICIDE IN NORTH CAROLINA, 2023. Dph. Accessed January 2026. https://www.dph.ncdhhs.gov/chronic-disease-and-injury/injury-and-violence-prevention/overall-suicide-fact-sheet/open
12Substance Misuse in Western North Carolina - WNC Health Network. Wnchn. Accessed January 2026. https://www.wnchn.org/wnc-data/substance-misuse-2/
13Drug Overdose Trends in North Carolina and Potential .... Nciom. Published 2018. Accessed January 2026. https://nciom.org/drug-overdose-trends-in-north-carolina-and-potential-impacts-of-the-one-big-beautiful-bill-act-obbba/
14Evidence-based treatment for opioid use disorder is widely .... ScienceDirect. Accessed January 2026. https://www.sciencedirect.com/science/article/pii/S2949875924001863
15North C. North Carolina's Opioid and Substance Use Action Plan | NCDHHS. Ncdhhs. Published 2017. Accessed January 2026. https://www.ncdhhs.gov/about/department-initiatives/overdose-epidemic/north-carolinas-opioid-and-substance-use-action-plan
16Medications for Opioid Use Disorder - UNC School of Medicine. Med. Accessed January 2026. https://www.med.unc.edu/fammed/nctac/resources-2/jail-based-mat/